Oncology Press Release Archive 2020-2017

I spearheaded Oncology research writing at Impact Journals, managing social media, podcasts, and press releases. Led a team, raised web traffic by 39.8%, and resolved SEO challenges, expanding global impact. Presented at industry conferences and pioneered multimedia content for the #1 Oncology journal in the world from 2017-2021.

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I became an expert at plain languaging oncology-focused, peer-reviewed, open access research to bridge gaps between specialties in cancer research, oncology, and biomedical sciences. My work aimed to unite diverse fields and apply both basic and clinical science.

I covered research about all molecules, pathways, cellular functions, and tissues as potential targets not only for cancer but also for various diseases which fostered a holistic understanding of disease mechanisms.

Oncotarget launches special collection on breast cancer

Breast Cancer Collection published in honor of breast cancer awareness.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

1-Dec-2020

IGF2 expression in breast cancer tumors and in breast cancer cells

"The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer."

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

19-Nov-2020

IGF2 expression in breast cancer tumors and in breast cancer cells

The Oncotarget authors propose that methylation of DVDMR represents a novel epigenetic biomarker that determines the levels of IGF2 protein expression in breast cancer.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

10-Nov-2020

Predictive biomarkers in Trop-2-expressing triple-negative breast cancer

SG could provide better clinical benefit than irinotecan in patients with HRR-proficient tumors expressing high levels of Trop-2, as well as to patients with HRR-deficient tumors expressing low/moderate levels of Trop-2.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

3-Nov-2020

Heterogeneity of CEACAM5 in breast cancer

Oncotarget recently published "Heterogeneity of CEACAM5 in breast cancer" which reported that Here, we examined a repository of 110 cryopreserved primary breast carcinomas by immunohistochemistry to assess the distribution of CEACAM5 in tumor subtypes.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/PRIMARY TUMORS

3-Nov-2020

Targeting breast cancer metabolism with a novel inhibitor

The Oncotarget author's data suggest in vitro proof-of-concept that supports inhibition of mitochondrial ATP synthase and ROS generation as contributors to the effectiveness of CADD522 in the suppression of tumor growth

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/ENZYMES/SYNTHASES

28-Oct-2020

KDM5A and PHF2 positively control expression of pro-metastatic genes

The cover for Issue 43 of Oncotarget features Figure 6, "(A) Following the experimental protocol of Franzetti et al. [11] A673-shA1c cells ?/+ Dox (EWS/Fli1high/EWS/Fli1low) were injected into the tail vein, and metastases were allowed to form in the absence of further Dox treatment (to allow recovery of cell growth in EWS/Fli1low cells),"

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/PHYSIOLOGY/PATHOPHYSIOLOGY/NEOPLASTIC PROCESSES/METASTASIS

27-Oct-2020

Oncotarget: An integrative microenvironment approach for follicular lymphoma

Oncotarget Volume 11, Issue 33 features Figure 8, "Haplotype estimates in follicular lymphoma patients," by Assis-Mendonça, et al. which reported that the authors tested associations between SNPs, clinicopathological features and TME composition, and proposed survival models in R-CHOP/R-CVP-treated patients.

PEER-REVIEWED PUBLICATION | /RESEARCH METHODS/OBSERVATIONAL STUDIES/LONGITUDINAL STUDIES/COHORT STUDIES

26-Oct-2020

Survival after resection of brain metastases: A matched cohort analysis

The cover for issue 32 of Oncotarget features Figure 2, "This figure depicts overall survival and local in-brain recurrence-free survival in the study's subgroups," by Hussein, et al. which reported that the aim of the present study is to assess whether the use of 5-ALA has an impact on local recurrence or survival compared to conventional white light microscopic tumor resection.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/BRAIN TUMORS

25-Oct-2020

Evaluation of cellular alteration & inflammatory profile of cells

Oncotarget recently published "Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis"

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL DEATH/CELL APOPTOSIS

24-Oct-2020

A novel format for recombinant antibody-interleukin-2 fusion proteins

Oncotarget recently published "A novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo which reported that here, the authors describe four novel formats for the L19-IL2 fusion, featuring different arrangements of antibody and IL2.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

23-Oct-2020

Thymoquinone induces apoptosis & DNA damage in 5-Fluorouracil-resistant colorectal cancer

Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/COLORECTAL CANCER

22-Oct-2020

Quantitative ultrasound radiomics in prediction of treatment response for breast cancer

The cover for Issue 42 of Oncotarget features Figure 4, "Generation of parametric and texture maps from radiofrequency data," recently published in "Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer" by Dasgupta, et al. which reported that to investigate quantitative ultrasound based higher-order texture derivatives in predicting the response to neoadjuvant chemotherapy in patients with locally advanced breast cancer.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

21-Oct-2020

Sirolimus-eluting stents -- opposite in vitro effects on the clonogenic cell potential

The cover for issue 31 of Oncotarget features Figure 4, "Concentration dose-response curves of sirolimus effect [55 nM-1 nM] on the number of cells per surviving colony in U2OS cell line after 2 weeks exposure," by Vasuri, et al. which reported that the authors evaluated the long-term effects of sirolimus on three different cell in vitro models, cultured in physiological conditions mimicking sirolimus-eluted stent, in order to clarify the effectiveness of sirolimus in blocking cell proliferation and survival.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/STEM CELLS/MESENCHYMAL STEM CELLS

21-Oct-2020

Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast

Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

20-Oct-2020

cGAS-STING pathway in oncogenesis and cancer therapeutics

Oncotarget Volume 11, Issue 30 reported that recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/SIGNAL TRANSDUCTION/INTERFERON SIGNALING

20-Oct-2020

Th1 cytokines potentiate apoptosis of breast cancer cells and suppress tumor growth

Volume 11, Issue 30 of Oncotarget reported that previously, the authors showed that anti-estrogen drugs combined with a dendritic cell-based anti-HER-2 vaccine known to induce strong Th1-polarized immunity dramatically improved clinical response rates in patients with HER-2pos/ERpos early breast cancer.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/IMMUNOLOGY/IMMUNE RESPONSE/CYTOKINES

18-Oct-2020

Induction of phenotypic changes in HER2-postive breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS/BREAST CANCER CELLS

17-Oct-2020

Geriatric nutritional risk index - prognostic marker of esophageal carcinoma

Oncotarget Volume 11, Issue 29 reported that In multivariate analyses, serum albumin, GNRI, pathological tumor-node-metastasis stage, and tumor differentiation were independent prognostic factors for CSS.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

16-Oct-2020

Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance

Oncotarget Volume 11, Issue 29 reported that Immunosuppressive chemoresistance is a major burden in lung cancer.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/LUNG TUMORS

15-Oct-2020

Genomic markers of midostaurin drug sensitivity in leukemia patients

Oncotarget Volume 11, Issue 29 reported that acute myeloid leukemia is a heterogeneous malignancy with the most common genomic alterations in NPM1, DNMT3A, and FLT3. Midostaurin was the first FLT3 inhibitor FDA approved for AML and is standard of care for FLT3 mutant patients undergoing induction chemotherapy.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/LEUKEMIA/MYELOID LEUKEMIA

14-Oct-2020

Efavirenz induces DNA damage response pathway in lung cancer

The cover for Issue 41 of Oncotarget features Figure 7, "IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells," recently published in "Efavirenz induces DNA damage response pathway in lung cancer" by Marima, et al. which reported that the cell-cycle related genes are potential gene targets in understanding the effects of efavirenz in lung cancer.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS

14-Oct-2020

miR-708-5p targets oncogenic prostaglandin E2 production in lung cancer cell

Volume 11, Issue 26 of Oncotarget reported that Lung cancer is of particular importance, as it is the deadliest cancer worldwide.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/LUNG TUMORS

13-Oct-2020

The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor

Volume 11, Issue 26 of Oncotarget reported that in this study the authors studied the differences in mi RNA expression between sporadic and FAP-associated Desmoid tumors using microarray confirmed by quantitative PCR.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/GASTROINTESTINAL NEOPLASMS

12-Oct-2020

Cooperative tumorigenic effects of targeted deletions of tumor suppressors

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/PANCREATIC TUMORS

11-Oct-2020

Characterization of porcine hepatocellular carcinoma for liver cancer

Volume 11, Issue 28 of Oncotarget features "Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation" by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA/HEPATOCELLULAR CARCINOMA

10-Oct-2020

Rapid onset type 1 diabetes with anti-PD-1 directed therapy

Volume 11, Issue 28 of Oncotarget features 'Rapid onset type 1 diabetes with anti-PD-1 directed therapy', by Yun et al. and reported that Type 1 diabetes is a rare immune-related adverse event caused by checkpoint inhibitors with serious risk for diabetic ketoacidosis.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/IMMUNE DISORDERS/AUTOIMMUNE DISORDERS/DIABETES/TYPE 1 DIABETES

9-Oct-2020

Exosomes secreted under hypoxia enhance stemness in Ewing's sarcoma

The cover for issue 40 of Oncotarget features Figure 5, "miR-210 silences the proapoptosis member CASP8AP2," by Kling, et al. which reported that hypoxic Ewing's sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS cells by enhancing survival.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL MORPHOLOGY/CELL STRUCTURE/ORGANELLES/VESICLES/EXOSOMES

8-Oct-2020

NRXN1 as a novel potential target for small cell lung cancer

The cover for issue 39 of Oncotarget features Figure 4, "Apoptosis assay of NRXN1-targeted ADC at IC50 dose calculated by growth inhibition curves," by Yotsumoto, et al. which reported that the authors identified transmembrane proteins overexpressed specifically in SCLC with little or no expression in normal tissues and decided to focus on the cell adhesion molecule neurexin-1.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

30-Sep-2020

A comprehensive analysis of clinical trials in pancreatic cancer

The cover for issue 38 of Oncotarget features Figure 3, 'Summary of the time and cost for drug development (modified from DiMasi et al [2016],' by Katayama, et al. which reported that Pancreatic cancer is the most aggressive common cancer and is desperately in need of novel therapies.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/PANCREATIC CANCER

23-Sep-2020

Oncotarget: ATM inhibition overcomes resistance to histone deacetylase inhibitor

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/ENZYME INHIBITORS/HDAC INHIBITORS

16-Sep-2020

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features Figure 7, 'Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model,' by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA

8-Sep-2020

Paradox breaker BRAF inhibitors in BRAF mutant colorectal cancer

Oncotarget Volume 11, Issue 34 features Figure 1, "BRAF inhibitor-induced changes in cell viability," by Pickles, et which reported that the BEACON CRC trial demonstrated a survival advantage over chemotherapy for a combination of targeted agents comprising the potent BRAF inhibitor encorafenib together with cetuximab and binimetinib.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/ENZYME INHIBITORS/EGFR INHIBITORS

25-Aug-2020

Oncotarget: Therapeutic efficacy of liposomal Grb2 antisense oligodeoxynucleotide (L-Grb2)

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling. In the present study, the authors examined the biological effects of liposomal antisense oligodeoxynucleotide that blocks Grb2 expression in gynecologic cancer models.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/OVARIAN CANCER

22-Jul-2020

The Golgi protein TMEM165 controls migration/invasion for carcinoma

The cover for issue 28 of Oncotarget features Figure 5, 'TMEM165 expression levels alters N-linked glycosylation,' by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENE EXPRESSION/EXPRESSION LEVELS

14-Jul-2020

Tumor markers for carcinoma identified by imaging mass spectrometry

Volume 11, Issue 28 of Oncotarget features 'Lipid and protein tumor markers for head and neck squamous cell carcinoma identified by imaging mass spectrometry' by Schmidt et, al. which reported that the authors used MALDI imaging mass spectrometry and immunohistochemistry to seek tumor-specific expression of proteins and lipids in HNSCC samples.

PEER-REVIEWED PUBLICATION | /RESEARCH METHODS/SPECTROSCOPY/MASS SPECTROMETRY

14-Jul-2020

A 3D biofabricated cutaneous squamous cell carcinoma tissue model

The cover for issue 27 of Oncotarget features Figure 4, "(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period," by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/SKIN TUMORS

7-Jul-2020

Correction of NSE concentration improves diagnostic accuracy in lung cancer

Oncotarget Volume 11, Issue 27 published "Correction of the NSE concentration in hemolyzed serum samples improves its diagnostic accuracy in small-cell lung cancer" by Genet et al. which reported that this study aimed to develop a hemolysis correction equation and evaluate its role in small-cell lung cancer (SCLC) diagnostics.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/LUNG CANCER

7-Jul-2020

Australian experience of peptide receptor radionuclide therapy

Oncotarget Volume 11, Issue 27 published "Australian experience of peptide receptor radionuclide therapy in lung neuroendocrine tumours" by Lim et al. which reported peptide receptor radionuclide therapy (PRRT) is an approved treatment modality for gastroenteropancreatic neuroendocrine tumours, although Phase III randomised clinical trial data is not available for NETs of other site of origin, in practice, PRRT is used more widely in clinical practice, based on its mechanism of targeting the somatostatin receptor.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/CLINICAL STUDIES/CLINICAL TRIALS

7-Jul-2020

Clonality and antigen-specific responses shape prognostic effects

Oncotarget Volume 11, Issue 27 reported that to delineate the complexity of anti-tumor T-cell responses, the author's utilized a computational method for de novo assembly of sequences from CDR3 regions of 369 high-grade serous ovarian cancers from TCGA, and then applied deep TCR-sequencing for analyses of paired tumor and peripheral blood specimens from an independent cohort of 99 ovarian cancer patients.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/OVARIAN CANCER

7-Jul-2020

Epigenetic feedback and stochastic partitioning can drive resistance to EMT

Oncotarget Volume 11, Issue 27 published "Epigenetic feedback and stochastic partitioning during cell division can drive resistance to EMT" by Jia et al. which reported that Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial transition are central to metastatic aggressiveness and therapy resistance in solid tumors.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/EPITHELIAL CELLS

7-Jul-2020

The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor

Volume 11, Issue 26 of Oncotarget reported that in this study the authors studied the differences in mi RNA expression between sporadic and FAP-associated Desmoid tumors using microarray confirmed by quantitative PCR.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/GASTROINTESTINAL NEOPLASMS

30-Jun-2020

IQGAP1 control of centrosome function defines variants of breast cancer

The cover for issue 26 of Oncotarget features Figure 6, 'Mislocalization of IQGAP1-BRCA1 in human TNBC tumors phenocopies the dominant mutants and the TNBC cells,' by Osman, et al. and reported that IQGAP1 is a signaling scaffold implicated in TNBC, but its mechanism is unknown.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL MORPHOLOGY/CELL STRUCTURE/ORGANELLES/CENTROSOMES

30-Jun-2020

RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation

The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL DEATH/CELL APOPTOSIS

23-Jun-2020

Mutation profile of primary subungual melanomas in Caucasians

Volume 11 Issue 25 of @Oncotarget reported that this study aimed to define the mutation profile of SUM in Caucasians.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/SKIN CANCER/MELANOMA

23-Jun-2020

Postoperative atrial fibrillation does not impact on overall survival after esophagectomy

Volume 11, Issue 25 of Oncotarget reported that Administration of landiolol hydrochloride was found to be associated with reduced incidence of atrial fibrillation after esophagectomy for esophageal cancer in our previous randomized controlled trial.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/ESOPHAGEAL CANCER

23-Jun-2020

Bacteriome and mycobiome and bacteriome-mycobiome interactions

Volume 11 Issue 25 of @Oncotarget reported that the authors aimed to characterize the bacteriome, mycobiome, and mycobiome-bacteriome interactions of oral wash in Head and neck squamous cell carcinoma, or HNSCC, patients and to determine if they are distinct from those of the oral wash of matched non-Head and neck squamous cell carcinoma patients.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA/SQUAMOUS CELL CARCINOMA

23-Jun-2020

Oncotarget: Indoximod opposes the immunosuppressive effects mediated by IDO and TDO

Volume 11 Issue 25 of Oncotarget reported that Indoximod has shaped the understanding of the biology of IDO1 in the control of immune responses, though its mechanism of action has been poorly understood.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/NEURONS/CELL BODIES/NEURITES/DENDRITES

23-Jun-2020

Tumor suppressor p53 regulates insulin receptor gene expression

Volume 11, Issue 25 of @Oncotarget reported that the present study was aimed at evaluating the hypothesis that p53 governs the expression and activation of the INSR gene in breast cancer cells.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/NUCLEIC ACIDS/DNA/DNA STRUCTURE/DNA REGIONS/PROMOTER REGIONS

23-Jun-2020

Preoperative geriatric nutritional risk index is a useful prognostic indicator

The cover for issue 24 of Oncotarget features Figure 4, 'Cancer-specific survival curves based on GNRI according to pTNM stage,' by Hirahara, et al. Volume 11 Issue 24 of @Oncotarget reported that this study aimed to evaluate the relationship between preoperative Geriatric Nutritional Risk Index and long-term outcomes in elderly gastric cancer patients.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/ONCOLOGY/CANCER PATIENTS

16-Jun-2020

Adoptive cell therapy in combination with checkpoint inhibitors

Volume 11, Issue 22 of @Oncotarget reported that there are rationale and evidence supporting immune therapy in Ovarian Cancers. The authors investigated the potential for adoptive cell therapy from in vitro expanded tumor-infiltrating lymphocytes in combination with checkpoint inhibitors and conducted immunological testing of ex vivo expanded TILs.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/OVARIAN CANCER

10-Jun-2020

Hyperprogression to immune blockade followed by a response with cabozantinib

Volume 11, Issue 22 of @Oncotarget reported that more and more patients receive first-line treatment with immunotherapy combinations and not all patients respond in metastatic renal cell carcinoma.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

10-Jun-2020

Exploring the role of survivin in neuroendocrine neoplasms

Volume 11, Issue 23 of @Oncotarget reported that tissue microarrays of 132 patients were stained for survivin using immunohistochemistry and correlated with outcomes.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENE EXPRESSION

10-Jun-2020

The role of EGFR mutations in predicting recurrence in lung adenocarcinoma

Volume 11, Issue 22 of @Oncotarget reported that while lobectomy can improve mortality in this group, about 30 55% of patients will experience disease recurrence.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

10-Jun-2020

miR-151a enhances Slug dependent angiogenesis

Volume 11, Issue 23 of @Oncotarget reported that the authors have previously established that mi R-151a functions as an onco-mi R in non-small cell lung cancer cells by inducing partial EMT and enhancing tumor growth.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/VASCULAR CELLS/ENDOTHELIAL CELLS

10-Jun-2020

Anticancer effect of physical activity is mediated

Volume 11, Issue 22 of Oncotarget reported that the goal of this study was to explore the involvement of mi RNAs in beneficial effects exerted by physical activity in breast cancer prevention.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

3-Jun-2020

Second line trastuzumab emtansine following horizontal dual blockade

Volume 11, Issue 22 of Oncotarget reported that despite relevant medical advancements, metastatic breast cancer remains an incurable disease.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

3-Jun-2020

An exploratory study of metformin and rapamycin as maintenance therapy

Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/PANCREATIC CANCER

27-May-2020

Loss of p16 and high Ki67 labeling index is associated with poor outcome

Oncotarget Volume 11, Issue 12 reported that the p16 tumor suppressor is coded by CDKN2A and plays an important role during carcinogenesis and tumor progression in numerous tumor entities.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/SKIN TUMORS

6-May-2020

Clinical implications of chromatin accessibility in human cancers

Volume 11, Issue 18 of @Oncotarget Clinical implications of chromatin accessibility assessed by ATAC-seq profiling in human cancers especially in a large patient cohort is largely unknown.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/ONCOLOGY/CANCER PATIENTS

5-May-2020

Combinations of paclitaxel and withaferin A against human non-small cell lung cancer

Oncotarget Volume 11 Issue 16 showed that the sensitivity of H1299 and A549 cells to concomitant treatment with PAC and WFA was greater than that of either PAC or WFA alone.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/LUNG CANCER

22-Apr-2020

Human papillomavirus confers radiosensitivity in oropharyngeal cancer cells

The cover for issue 16 of Oncotarget features Figure 6, 'Radiation-induced DNA damage measured by γ-H2AX foci formation at a specified time point after 10 Gy irradiation,' by Zhang, et al.

PEER-REVIEWED PUBLICATION | /PHYSICAL SCIENCES/PHYSICS/ENERGY/RADIATION

21-Apr-2020

Characterization of iPS87, a prostate cancer stem cell-like cell line

Oncotarget Volume 11, Issue 12 reported outside its natural niche, the cultured prostate cancer stem cells lost their tumor-inducing capability and stem cell marker expression after approximately 8 transfers at a 1:3 split ratio.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/PROSTATE CANCER

27-Mar-2020

Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment

Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL DEVELOPMENT/CELL DIFFERENTIATION

26-Mar-2020

hPCL3S promotes proliferation and migration of androgen-independent prostate cancer cells

The cover for issue 12 of Oncotarget features Figure 11, 'Global analyses of the RNA-Seq data of LNCaP empty vector and LNCaP cells overexpressing hPCL3S (Clone 12)' by Abdelfettah, et al.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/PROTEIN FUNCTIONS/PROTEIN DOMAINS/DNA BINDING DOMAINS

25-Mar-2020

DOT1L inhibition is lethal for multiple myeloma due to perturbation

Oncotarget Volume 11, Issue 11 reported that in order to understand the molecular mechanism of the dependency in MM, the research team examined gene expression changes upon DOT1L inhibition in sensitive and insensitive cell lines and discovered that genes belonging to the endoplasmic reticulum stress pathway and protein synthesis machinery were specifically suppressed in sensitive cells.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CELL LINES

20-Mar-2020

Early prediction of resistance to tyrosine kinase inhibitors

Oncotarget Volume 11, Issue 11 reported that at clinical progression, 64 EGFR T790M plasma positive patients were subjected to second line-treatment with osimertinib and strictly monitored during the first month of therapy. Plasma analysis by the EGFR Cobas test showed in 57 cases a substantial decrease in the levels of the sensitizing EGFR mutant allele, down to a not detectable value.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

20-Mar-2020

Acute promyelocytic leukemia (APL): a review of the literature

Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem. The probability of relapse is significantly higher in the high-risk subset of patients undergoing treatment for APL; overall approximately 10-20% of APL patients relapse regardless of their risk stratification.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

20-Mar-2020

Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity

Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors. Dr. Takeshi Isoyama from Daiichi Sankyo Co., Ltd. said, "FMS like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase expressed by acute myeloid leukemia (AML) cells in 70% to 90% of patients."

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/LEUKEMIA/MYELOID LEUKEMIA

20-Mar-2020

Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy

The cover for issue 11 of Oncotarget features Figure 6, 'Effects of AZD8186 in combination with anti-PD1 on syngeneic models,' by Owusu-Brackett, et al. In vitro cell viability assay and immunoblotting demonstrated that PTEN loss was significantly correlated with AZD8186 sensitivity in triple-negative breast cancer cell lines.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS/BREAST CANCER CELLS

18-Mar-2020

Prognostic and predictive factors in pancreatic cancer

Oncotarget Volume 11, Issue 10 reported that there are not standardized predictive biomarkers able to identify patients who benefit most from treatments.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/PANCREATIC CANCER

13-Mar-2020

MicroRNA (miR) dysregulation during Helicobacter pylori-induced gastric

Oncotarget Volume 11, Issue 10 reported that dysregulation of noncoding micro RNA molecules has been associated with immune cell activation in the context of Helicobacter pylori-induced gastric inflammation as well as carcinogenesis, but also with downregulation of mismatch repair genes, and may interfere with immune checkpoint proteins that lead to the overexpression of antigens on gastric tumor cells.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENETIC MATERIAL/RNA/MICRORNA

13-Mar-2020

Oncotarget: A microRNA-based signature predicts local-regional failure and overall survival

The cover for issue 10 of Oncotarget features Figure 3, 'Overall survival (OS) for high (red) versus low (black) risk groups in the (A) OSU, (B) TCGA, and (C) SNU resected cohorts,' by Wolfe, et al.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

13-Mar-2020

DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques

Oncotarget Volume 11, Issue 10 reported that the statistically associated Cp G sites were analyzed in blood samples from two separate atherothrombotic stroke cohorts, ischemic stroke-cohort 1: 37 atherothrombotic patients and 6 controls, ischemic stroke-cohort 2: 80 atherothrombotic patients and 184 controls.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/HEMATOLOGY/BLOOD SAMPLES

13-Mar-2020

Inducible knock-out of BCL6 in lymphoma cells results in tumor stasis

An oncogenic role of BCL6 in the initiation of DLBCL has been shown as the constitutive expression of BCL6 in mice recapitulates the pathogenesis of human DLBCL. Conditional BCL6 deletion in established DLBCL tumors in vivo induced a significant tumor growth inhibition with initial tumor stasis followed by slow tumor growth kinetics.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/ONCOLOGY/TUMOR GROWTH

4-Mar-2020

SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism

Oncotarget Volume 11 Issue 8 reported that while it is known that cancer cells require one-carbon and FAD-dependent mitochondrial metabolism to sustain cell proliferation, the role of SLC25A32 in cancer cell growth remains unexplored.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS

28-Feb-2020

Oncotarget: Both BRCA1-wild type and -mutant triple-negative breast cancers show

Oncotarget Volume 11 Issue 8 features Figure 8, 'MLN4924 treatment induces DNA damage by stabilizing CDT1 and accumulates the cells in S phase which are enhanced by MLN4924/cisplatin co-treatment,' by Misra, et al.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/DNA DAMAGE

26-Feb-2020

A randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared...

The objective of this study was to compare the safety and antitumor activity of F14512 and etoposide phosphate in dogs with spontaneous non-Hodgkin lymphoma and to investigate the potential benefit of F14512 in P-glycoprotein overexpressing lymphomas.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANIMALS/VERTEBRATES/MAMMALS/DOGS

19-Feb-2020

Empty SV40 capsids increase survival of septic rats by eliciting numerous host signaling networks

The cover for issue 6 of Oncotarget features Figure 3, 'The effect of NCs treatments on routine lab results during disease and recovery progress,' by Ben-Nun-Shaul, et al.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

12-Feb-2020

Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer

Oncotarget Volume 11, Issue 4: In this study, locally advanced head and neck cancer patients undergoing definitive chemoradiation were randomly allocated to weekly cisplatin - radiation {CRT arm} or nimotuzumab -weekly cisplatin -radiation {NCRT arm}.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

6-Feb-2020

Tumor secreted ANGPTL2 facilitates recruitment of neutrophils to the lung to promote lung pre-metastatic niche formation and targeting ANGPTL2 signaling affects metastatic disease

The authors determined that tumor-derived ANGPTL2 stimulates lung epithelial cells, which is essential for primary tumor-induced neutrophil recruitment in lung and subsequent pre-metastatic niche formation.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/RESPIRATORY SYSTEM/LUNGS

5-Feb-2020

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell

Oncotarget Volume 11, Issue 4: Treatment of human oral squamous cell carcinoma cell lines HSC3 and HSC4 with Clostridium perfringens enterotoxin, induced CLDN4 nuclear translocation to enhance epithelial-mesenchymal transition, stemness, cell proliferation, and invasive ability.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/MICROBIOLOGY/BACTERIOLOGY/BACTERIA/ANAEROBIC BACTERIA

4-Feb-2020

Overall survival in patients with lung adenocarcinoma harboring 'niche' mutations

Mutations were observed in all genes studied, except c-MET, DDR2, MAP2K1, and RET. The multivariable analysis showed that: Niche mutations had higher mortality than EGFR mutations KRAS mutations had higher mortality than EGFR mutations, and Niche mutations presented similar mortality to KRAS mutations.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/GENETIC METHODS/GENETIC ANALYSIS/MUTATIONAL ANALYSIS

4-Feb-2020

Anti-carcinoembryonic antigen-related cell adhesion molecule antibody for fluorescence visualization

Oncotarget Volume 11, Issue 4: The research team's aim was to investigate mAb 6G5j binding characteristics and to validate fluorescence targeting of colorectal tumors and metastases in patient derived orthotopic xenograft models with fluorescently labeled 6G5j.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/GASTROINTESTINAL NEOPLASMS

31-Jan-2020

Low-dose metronomic cyclophosphamide complements the actions of an intratumoral C-class CpG TLR9 agonist to potentiate innate immunity and drive potent T cell-mediated anti-tumor responses

Intratumoral injection of SD-101 induces significant anti-tumor immunity in preclinical and clinical studies, especially when combined with PD-1 blockade.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER

31-Jan-2020

Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling pro

In addition to 4 reported PMEPA1 isoforms, one novel isoform PMEPA1-e was identified with RNA Seq analysis of hormone-responsive VCa P, LNCa P cells and human prostate cancer samples from The Cancer Genome Atlas dataset.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/PROTEINS/ISOFORMS

31-Jan-2020

Inherited DNA-repair gene mutations in African American men with prostate cancer

Oncotarget Volume 11, Issue 4: Pathogenic or likely pathogenic alterations in these 14 DNA repair genes were less likely to be detected in African Americans as compared to Caucasians.

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/ANTHROPOLOGY/CULTURAL ANTHROPOLOGY/ETHNICITY

31-Jan-2020

The virome of HPV-positive tonsil squamous cell carcinoma and neck metastasis

In this prospective study, a pan-pathogen microarray was used to determine the virome of early stage, p16-positive OPSCC and neck metastasis treated with transoral robotic surgery and neck dissection.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/NECK

27-Jan-2020

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development

In the present study, the research team investigated AEZS-108 induced cytotoxicity and the altered mRNA expression profile of regulatory factors related to angiogenesis and metastasis in LHRH receptor-positive OCM3 cells.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/DEVELOPMENTAL BIOLOGY/ONTOGENY/MORPHOGENESIS/ANGIOGENESIS

14-Jan-2020

Identification of signature genes associated with therapeutic resistance to anti-VEGF therapy

To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/OVARIAN CANCER

8-Jan-2020

Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation

Molecular subtypes based on copy number, DNA methylation, and mRNA expression had variable proliferation levels, the highest correlating with decreased survival.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/MRNA EXPRESSION

11-Dec-2019

A mouse model of prostate cancer bone metastasis in a syngeneic immunocompetent host

The research team reports the establishment of B6Ca P, an allograft tumor line from a Hi-Myc transgenic mouse that had been backcrossed onto C57BL/6J background.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/METASTASIS

4-Dec-2019

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis

In this study, the research team investigated NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies that had been subjected to whole exome sequencing.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

4-Dec-2019

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment. Further studies on API-5 expression and inhibition were performed on patient-derived TNBC xenografts, one highly sensitive to chemotherapies and the other resistant to most tested drugs.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS/CHEMOTHERAPY

25-Nov-2019

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant...

Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system. Comparing NSCLC PE and published plasma levels of CAR-T recipients, both were dominated by sIL-6R and IL-6 but NSCLC PE had more VEGF, FGF2 and TNF, and less IL-2, IL-4, IL-13, IL-15, MIP1 and IFN.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/MESOTHELIOMA

22-Nov-2019

Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models

The cover for issue 62 of Oncotarget features Figure 7, 'Proposed model of the hyperploid pathway as a salvage survival strategy regulated by the G2-M checkpoint,' by Yeung, et al.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/NEOPLASTIC CELLS/TUMOR CELLS

19-Nov-2019

High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment. Further studies on API-5 expression and inhibition were performed on patient-derived TNBC xenografts, one highly sensitive to chemotherapies and the other resistant to most tested drugs. Clinical analyses of the 78 TNBC biopsies revealed that API-5 was more markedly expressed in endothelial cells before any treatment among patients with chemoresistant TNBC, and this was associated with greater micro-vessel density.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS/CHEMOTHERAPY

13-Nov-2019

Getting cancer drugs to the brain is difficult -- but a new 'road map' might make it easier

Purdue University scientists have provided the first comprehensive characterization of both the blood-brain and blood-tumor barriers in brain metastases of lung cancer, which will serve as a road map for treatment development. The work was recently published in Oncotarget.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/NERVOUS SYSTEM/CENTRAL NERVOUS SYSTEM/BLOOD BRAIN BARRIER

12-Nov-2019

Secretome of pleural effusions associated with non-small cell lung cancer (NSCLC) and malignant meso

Cryopreserved cell-free PE fluid from 101 NSCLC patients, 8 mesothelioma and 13 with benign PE was assayed for a panel of 40 cytokines/chemokines using the Luminex system.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/MESOTHELIOMA

5-Nov-2019

Dynamic transition of the blood-brain barrier in the development of non-small cell lung cancer brain

Effective drug delivery through the BTB is one of the greatest therapeutic obstacles in treating brain metastases. Using an experimental model, the researchers defined key changes within the BTB and the BBB in the brain around the tumor region over time. These data provide a comprehensive analysis of the BTB in NSCLC brain metastasis.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/PHYSIOLOGY/PATHOPHYSIOLOGY/NEOPLASTIC PROCESSES/METASTASIS

31-Oct-2019

Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein

In the CRC patients, KLK6 protein levels were elevated in the non-cancerous distant and adjacent tissues, compared to their paired tumor tissues. Patients with mutant K-RAS tumors had significantly higher level of KLK6 protein in the luminal surface of non-cancerous distant tissue, compared to the corresponding tissues of the patients with K-RAS wild type tumors.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/TUMOR TISSUE

22-Oct-2019

Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma

High levels of circ E7 by quantitative RT-PCR predicted improved overall survival in ASCC and analysis of The Cancer Genome Atlas sequencing from HPV-positive head and neck cancer and cervical cancer suggested high circ E7 marked improved survival in 875 subjects.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

16-Oct-2019

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity

The researchers have recently identified the tumor suppressor tuberous sclerosis complex 1 as a new co-chaperone of Hsp90 that affects Hsp90 binding to its inhibitors. Their findings suggest that TSC1 status may predict response to Hsp90 inhibitors in patients with bladder cancer, and co-targeting HDACs can sensitize tumors with Tsc1 mutations to Hsp90 inhibitors.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

10-Oct-2019

Oncotarget editorial board members William G Kaelin Jr. and Gregg L Semenza win 2019 Nobel Prize

The 2019 Nobel Prize in Physiology or Medicine has been awarded jointly to Oncotarget Editorial Board Members William G. Kaelin Jr. and Gregg L. Semenza for their discoveries of how cells sense and adapt to oxygen availability.

GRANT AND AWARD ANNOUNCEMENT | /SOCIAL SCIENCES/SOCIAL STUDIES OF SCIENCE/SCIENCE HISTORY/NOBEL PRIZES

10-Oct-2019

Inhibition of histone deacetylase 2 reduces MDM2 expression and reduces tumor growth in dedifferentiated liposarcoma

Here the researchers present in silico, in vitro, and mouse xenograft studies that suggest that specifically targeting HDAC2 reduces MDM2 expression and has anti-tumor affects in DDLPS. In a murine DDLPS xenograft model, romidepsin reduced tumor growth and lowered tumor MDM2 expression.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/TRANSPLANTATION/XENOGRAFTS

4-Oct-2019

Impact of exosomal HIV-1 Tat expression on the human cellular proteome

The researcher's previous work has demonstrated that exosomal formulations of Tat can reverse HIV-1 latency in primary CD4+ T lymphocytes isolated from long term antiretroviral treated individuals suggesting a potential role for Tat as a therapeutic HIV-1 Latency Reversal Agent.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/PROTEIN FUNCTIONS/PROTEIN EXPRESSION

4-Oct-2019

Substance found in grapes prevents agglomeration of a mutant protein that leads to cancer

A novel Brazilian study published in Oncotarget is the first to show the action of resveratrol, a bioactive compound present in grapes and red wine, on the inhibition of aggregates of the mutant p53 protein. Because they are found in more than half of human malignant tumors, these amyloid aggregates are considered strategic targets in the fight against cancer.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/BREAST CANCER

26-Jun-2018

Siamab Therapeutics announces publication of new data on its ST1 lead program in the journal Oncotarget

Siamab Therapeutics Inc., a biopharmaceutical company developing novel glycan-targeted cancer therapeutics, today announced the publication of new preclinical data.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/OVARIAN CANCER

1-May-2018

OncoDNA announces publication of peer-reviewed study in Oncotarget assessing the utility of its unique biomarker analysis and interpretation platform in clinical decision making

OncoDNA treatment recommendation followed in 60% of cases. 93% of treatment decisions were made based on a holistic approach combining next generation sequencing (NGS) and multiple biomarker analysis provided by OncoDNA. 27% of late-stage patients treated with OncoDNA-recommended therapies had overall survival >12 months, compared to a typical average of no more than six months.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL DIAGNOSIS/BIOMARKERS

17-Apr-2018

Oncotarget to be indexed in highly esteemed meta database

Oncotarget announced that its peer-reviewed research publications will be indexed in Meta, a world-renowned database of scientific literature, alongside other Impact Journal publications. Meta was acquired by the Chan Zuckerberg Initiative in an effort to make Meta's artificial intelligence (AI) technologies available to enhance scientists' ability to search, read, and tie together millions of scientific papers.

BUSINESS ANNOUNCEMENT | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

12-Mar-2018

Cancer pioneer employs physics to approach cancer in last research article

In the cover article of Tuesday's issue of Oncotarget, James Frost, MD, PhD, Kenneth Pienta, MD, and the late Donald Coffey, Ph.D., use a theory of physical and biophysical symmetry to derive a new conceptualization of cancer. Co-author Dr. Coffey, ex-deputy director of the Johns Hopkins Kimmel Cancer Center and Professor of Urology, died before this paper was published at 85.

PEER-REVIEWED PUBLICATION | /APPLIED SCIENCES AND ENGINEERING/SYSTEMS THEORY/PATTERN FORMATION/NATURAL PATTERNS/SYMMETRY

20-Feb-2018

Scientists identify genes implicated in the high regenerative capacity of embryos and ESCs

Researchers at Insilico Medicine, AgeX Therapeutics and the Biogerontology Research Foundation have published a landmark study titled 'Use of deep neural network ensembles to identify embryonic-fetal transition markers: repression of COX7A1 in embryonic and cancer cells' in the journal Oncotarget.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/DEVELOPMENTAL BIOLOGY/REGENERATION/TISSUE REGENERATION

16-Jan-2018

Deep learning methods used to identify novel genes implicated in tissue regeneration and cancer

The latest publication by Insilico Medicine and BioTime in Oncotarget demonstrated the first application of deep neural networks (DNNs) to the gene expression data collected during many stages of differentiation starting from several embryonic stem cell lines. Repression of COX7A1 in embryonic and cancer cells was identified as embryonic-fetal transition markers by DNN.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENE EXPRESSION

4-Jan-2018

Researchers identify novel therapeutic strategy for drug-resistant thyroid cancers

New findings by a Harvard Medical School team suggest that palbociclib, a drug that is FDA-approved to treat advanced breast cancer, may be able to overcome vemurafenib resistance in PTC.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/PHARMACOLOGY/DRUG RESISTANCE

20-Dec-2017

Researchers identify a potential molecular trigger for invasiveness in prostate cancer cells

A small protein modification can trigger the aggressive migratory and invasive properties of prostate cancer cells, according to new research published on the cover of Oncotarget. The findings give greater insight into how cancers can move from one location in the body to another, and could help develop more effective therapies in the future. Editorial by Xin Ye and Robert A. Weinberg can be found online.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

20-Dec-2017

Individuals in the US diagnosed with cancer are 2.7 times more likely to declare bankruptcy than individuals without cancer, study finds

As advancements in cancer therapies have been making headlines in recent years, cancer drug prices have significantly increased. The remaining question is, what are the economic impacts of the differentiations in cost of FDA approved drugs and the purchasing power of individuals around the world? This study, published in Oncotarget, titled "A global comparison of the cost of patented cancer drugs in relation to global differences in wealth" identifies several critical factors impacting cancer patients.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS/CANCER MEDICATION

20-Dec-2017

New Oncotarget podcast launched today

Oncotarget launches a series of podcasts that will allow scientists to delve deeper into a variety of research contributions found in the journal.

BUSINESS ANNOUNCEMENT | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

19-Dec-2017

Researchers find possible markers for earlier diagnosis of aggressive tongue cancer

Squamous cell carcinoma of the tongue, also known as oral tongue cancer, is an aggressive form of cancer that generally affects older people. in a new study published in Oncotarget, a team of researchers has found that bacterial diversity and richness, and fungal richness, are significantly reduced in tumor tissue compared to their matched non-tumor tissues.

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

19-Dec-2017

Oncotarget awards grants to four biomedical researchers at Frontiers in Cancer Science

Oncotarget, the world's largest oncology peer-reviewed research publication, awarded travel grants enabling four biomedical researchers to attend November's Frontiers in Cancer Science 2017 (FCS 2017) conference in Singapore. The travel sponsorship encourages the discussion of cancer discoveries in support of Oncotarget's commitment to maximizing the circulation of scientific research.

GRANT AND AWARD ANNOUNCEMENT | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

19-Dec-2017

Oncotarget now publishing two issues a week available in PubMed and other high profile scientific research indexes and archives

Oncotarget, a distinguished multidisciplinary bio-medical journal, reassured readers this week that all of its scientific publications are and will continue to be available on PubMed, PubMed Central, ISI/Web of Science: Science Citation Index Expanded, Scopus, Biological Abstracts, BIOSIS Previews, and EMBASE. In cooperation with the National Library of Medicine, Oncotarget is achieving its goal to become the first research journal to submit an entire issue to PubMed just days after online publication.

BUSINESS ANNOUNCEMENT | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

19-Dec-2017

Researchers identify potential therapeutic target in aggressive breast cancer cells

An especially aggressive breast cancer cell can respond to hormone therapy if they express a specific protein known as estrogen receptor beta, according to research published in Oncotarget.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS/BREAST CANCER CELLS

15-Dec-2017