VIDEO PRODUCTION
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Beyond my professional achievements such as 6 years experience as a Final Cut Pro certified video editor my passion for storytelling has driven me to invite, record, edit, and publish captivating video interviews and YouTube channels, delving into the realms of science, medicine, and technology.
These endeavors not only demonstrate my technical prowess but also highlight my deep-seated curiosity and commitment to making complex subjects accessible to everyone.
As you navigate through this video portfolio, you will witness the culmination of my almost decade experience and unwavering dedication to impactful communication.
Whether you seek innovative video production, strategic marketing insights, or a visionary collaborator to breathe life into your ideas, you have come to the right place.
"Molecular signatures of age-associated chronic degeneration of shoulder muscles" which reported that shoulder complaints are highly common in the elderly, and therefore, muscles of the shoulder's rotator cuff could be considered as a model for chronic age-associated muscle degeneration.
Oncotarget published "LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer" which reported that the authors performed global gene expression profiling of mammary epithelial cells transformed by oncogenic v-Src, and identified a large subset of uncharacterized lncRNAs potentially involved in breast cancer development.
"Osteoprotegerin rich tumor microenvironment: implications in breast cancer" which reported that Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor -related apoptosis inducing ligand.
An especially aggressive breast cancer cell can respond to hormone therapy if they express a specific protein known as estrogen receptor beta (ERβ), according to new research published on the cover of Oncotarget. The findings also revealed additional molecules that the researchers suggest targeting to develop drugs for this breast cancer type
"PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans" which reported that Class-I phosphatidylinositol 3-kinase converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate.
Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs" which reported that the role of Wnt signalling in male germ cells remains poorly understood.
"PIP3-binding proteins promote age-dependent protein aggregation and limit survival in C. elegans" which reported that Class-I phosphatidylinositol 3-kinase converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 3,4,5-triphosphate.
"Cis-acting elements in its 3′ UTR mediate post-transcriptional regulation of KRAS" which reported that the KRAS gene encodes a key signaling protein, and its messenger RNA contains an exceptionally long 3′ UTR; this suggests that it may be subject to a highly complex set of regulatory processes.
"Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation" which reported that To model this sequential genetic cooperativity, we coupled somatic lentivirus-mediated p53 knockdown in the adult right sciatic nerve with embryonic Schwann cell precursor Nf1 gene inactivation in two different Nf1 conditional knockout mouse strains.
Prof. Malka Cohen-Armon from the Sackler Faculty of Medicine & the Sagol School of Neuroscience at Tel-Aviv University in Tel-Aviv, Israel said, "Despite a substantial advance in cancer treatment, pancreatic ductal adenocarcinoma (PDAC) have a limited response to current treatments, and a low 5-years survival rate of about 6%."
"Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas" which reported that In this study, we sought to define a threshold value for positive PRAME expression in a large dataset, identify factors associated with PRAME expression, evaluate the prognostic value of PRAME in Class 2 uveal melanomas, and determine whether PRAME expression is associated with aberrant hypomethylation of the PRAME promoter.
"Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model" which reported that the Runx genes function as dominant oncogenes that collaborate potently with Myc or loss of p53 to induce lymphoma when overexpressed.
Dr. Beatrice Aramini from the University of Modena and Reggio Emilia in Modena Italy about their Featured Cover Paper for Volume 11 Issue 5 titled "Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study"
Dr. Stuart A. Aaronson from The Icahn School of Medicine at Mount Sinai said, "The Hippo pathway is an evolutionarily conserved signaling pathway that plays a fundamental role in growth control, stem cell function, tissue regeneration, and tumor suppression."
"Our findings suggest for the first time that a combination drug therapy using vemurafenib and palbociclib represents a novel therapeutic strategy to treat PTC," said lead author of the study Carmelo Nucera M.D., Ph.D., an assistant professor at Harvard Medical School.
Dr. Jonathan A. Kelber from The California State University Northridge said, "Next-Generation Sequencing (NGS), such as RNA-seq or whole-genome analysis, of patient-derived tumor tissue in combination with state-of-the art bioinformatics holds great potential to improve disease outcomes by identifying novel biomarkers of cancer onset, progression and therapy resistance."
"Addiction to Runx1 is partially attenuated by loss of p53 in the Eμ-Myc lymphoma model" which reported that the Runx genes function as dominant oncogenes that collaborate potently with Myc or loss of p53 to induce lymphoma when overexpressed.
Dr. Dean W. Felsher from Stanford University, and Founding Editorial Board member of Oncotarget said, "Although cancers evolve through a multistage process with accumulation of both genetic and epigenetic changes, many cancers are dependent on specific driver oncogenes for maintenance of the malignancy"
Dr. Markus D. Siegelin from The Columbia University Medical Center said, "Amino acid metabolism might represent an “Achilles heel” in cancer since a number of tumors acquire an altered dependency on some of these metabolic pathways."
Dr. Boman presents from the Center for Translational Cancer Research to hasten discoveries from bench to bedside and draws us even closer on the path to targeted therapies that can improve survival and quality of life for patients with drug-resistant, advanced colorectal cancer.
"These results suggest that sumoylation of Snail1 might be a marker for prostate cancer progression," said Professor Marene Landström. "As sumoylation inhibitors are currently being tested to combat the development of breast cancer tumors, it would be interesting to see the effects of targeting Snail1 sumoylation in prostate cancer."
Dr. Sameek Roychowdhury from the Department of Internal Medicine, Division of Medical Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA said, "Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy of dendritic cell origin with approximately 100 cases reported to date"
Interview with Dr. Louis Chesler – Lead of the Pediatric Tumor Biology and Therapeutic Targeting Team, at the Institute of Cancer Research & the Royal Marsden NHS Trust, Children and Young People’s Unit, Sutton, Surrey, UK
Dr. Joyce Schroeder from The University of Arizona said, "Epithelial cells are regulated by apicobasal polarity complexes that provide an asymmetric cell structure, regulate growth and survival, migration and invasion, and differentiation."
Dr. Ira Pastan from The National Cancer Institute, National Institutes of Health said, "Recombinant immunotoxins (RITs) are antibody-toxin fusion proteins developed for cancer therapy."
Dr. Mehdi Mollapour and Dr. Gennady Bratslavsky, both from The SUNY Upstate Medical University said, "Worldwide nearly 338,000 people develop kidney cancer every year, and over 100,000 people die from the disease"
JMIR Publications is pleased to announce the expansion of their journal portfolio with JMIR Neurotechnology (JNT) a gold open access, peer-reviewed journal focused on the intersection between clinical neuroscience and technology to prevent, diagnose, and treat neurological disorders. This journal was launched due to the fact that advances in many domains are providing valuable contributions, ranging from new findings from basic research aimed at unraveling applied behavioral approaches to improve neurological functions and health-related qualit
JMIR Publications published a study titled “Competition and Integration of US Health Systems in the Post-COVID-19 New Normal: Cross-sectional Survey” in JMIR Formative Research, which reported that the smaller the geographical region in which mergers and acquisitions (M&A) activity is pursued, the higher the likelihood that monopolistic tendencies will result.
JMIR Publications published “Patient Design: The Importance of Including Patients in Designing Health Care” in the Journal of Medical Internet Research, which reported that patient design, instead of patient centricity, should lead healthcare leaders in designing products, facilities or technologies for patients
Dr. Alex Toker from Harvard Medical School Toker Lab said, "One of the most frequently deregulated pathways in human cancers is the phosphoinositide 3-kinase (PI 3-K) and Akt signaling cascade."
Dr. Gregory J. Riggins from Johns Hopkins University, said, "Gliomas are the most common type of malignant primary brain tumor, with ~17,000 newly diagnosed cases each year in the United States."
"The work was stimulated by many conversations I had with Don Coffey about the fundamental nature and fascination of symmetry we experienced," said lead author James Frost, M.D., Ph.D., and adjunct professor and professor emeritus of radiology at John Hopkins.
Dr. Gary S. Goldberg from Rowan University said, "Approximately 300,000 new cases of oral cancer are diagnosed each year, causing over 120,000 deaths worldwide".
Dr. Anita Bandrowski from the University of California San Diego said, "Research reproducibility is necessary for scientific progress. However, over the last decade, numerous reports on research irreproducibility have shed light on a lingering problem, one that is proving to be both troublesome and costly."
Dr. Dale Bredesen of Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, University of California, Los Angeles, CA and the Buck Institute for Research on Aging, Novato, CA
Dr. Robert J. Shmookler Reis and Dr. Srinivas Ayyadevara from the Reynolds Institute on Aging, Dept. of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR
Dr. Vilhelm A. Bohr from The National Institute on Aging, NIH, said, "The RecQ family of helicases contains highly conserved and ubiquitously expressed proteins that unwind DNA in the context of replication, repair, transcription, chromatin remodeling and telomere maintenance."
Dr. David A. Sinclair, Professor of Pathology and Co-Director of the Glenn Laboratories for Aging Research at Harvard Medical School "Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), which is responsible for the worldwide pandemic of coronavirus disease (COVID-19) originated in Wuhan, China, in late 2019."
Researchers from the NYU School of Medicine, the Perlmutter Cancer Center, UT MD Anderson Cancer Center, and the University of Massachusetts Medical School
Kara Fitzgerald ND IFMCP, from The Institute for Functional Medicine said, "Advanced age is the largest risk factor for impaired mental and physical function and many non-communicable diseases including cancer, neurodegeneration, type 2 diabetes, and cardiovascular disease."
Dr. Katherine M. Bever from The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, 21287 said, "Pancreatic ductal adenocarcinoma (PDA) is aggressive cancer with high mortality at all stages and limited treatment options in the advanced setting."
Dr. Bruno Larrivée from The University of Montreal said, "AMD is the leading cause of blindness in the aging populations of western industrialized countries."
Jonathan Kelber and Francesca Sanchez from the Department of Biology, California State University Northridge, Northridge CA
Dr. Steve Horvath - Department of Human Genetics and Biostatistics University of California, Los Angeles David Geffen School of Medicine
Dr. Stanley Lipkowitz, Chief, Women's Malignancies Branch, NCI said, "Our work identifies a novel mechanism of ONC201 cytotoxicity that is based on the disruption of mitochondrial function, leading to ATP depletion and cell death in cancer cells that are dependent on mitochondrial respiration. Our study also suggests that cancer cells that are dependent on glycolysis will be resistant to ONC201"
Dr. Beatrice Aramini from The University of Modena and Reggio Emilia said, "The cancer stem cell (CSC) model was proposed over 30 years ago [1] and is a very important field of study in cancer research."
Dr. Anita Bandrowski from the University of California San Diego said, "Research reproducibility is necessary for scientific progress. However, over the last decade, numerous reports on research irreproducibility have shed light on a lingering problem, one that is proving to be both troublesome and costly."
Professor Mohamed El-Tanani from the University of Bradford said, "Triple negative breast cancer has lower survival rates and increased risk of recurrence. It is the only type of breast cancer for which only limited targeted treatments are available. Our research has shown that Pimozide could potentially fill this gap. And because this drug is already in clinical use, it could move quickly into clinical trials."
Dr. René Bernards & Diede Brunen - Division of Molecular Carcinogenesis, The Netherlands Cancer Institute
Dr. Jaclyn Hechtman from the Department of Pathology Memorial Sloan Kettering Cancer Center
Dr. Anita Bandrowski from the University of California San Diego said, "Research reproducibility is necessary for scientific progress. However, over the last decade, numerous reports on research irreproducibility have shed light on a lingering problem, one that is proving to be both troublesome and costly."
Dr. Mary J. Janatpour from Dynavax Technologies, Inc., Emeryville, CA 94608, USA said, "It has long been appreciated by cancer researchers that the phenotypic heterogeneity and progressive evolution of malignant tumors minimize the chance that any agent targeting a single molecular pathway could effectively cure advanced cancer."
Aging Editorial Board member and Founder and CEO of Insilico Medicine, Dr. Alex Zhavoronkov
Dr. Anutosh Ganguly from the Department of Integrative Biology and Pharmacology, University of Texas Medical School
Dr. Mariana Perepitchka, Dr. Yekaterina Galat, and Dr. Vasiliy Galat discuss their 2020 research paper entitled, "Down syndrome iPSC model: endothelial perspective on tumor development."
Dr. Ganesh V. Halade from the Division of Cardiovascular Disease Department of Medicine, The University of Alabama at Birmingham, AL
Dr. Patricia Rousselle - Head of the Cell / Microenvironment Cross-Talk and Tissue Repair Laboratory in the Biologie Tissulaire et Ingénierie Thérapeutique Department in France
Dr. David Loeb, Pediatric Oncologist - Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Sarcoma Program
Dr. Benjamin Purow from the Departments of Neurology, University of Virginia, Charlottesville, VA 22908, USA said "The statins inhibit the HMG-CoA reductase enzyme and are among the most widely-prescribed drugs in the world for their cholesterol-lowering function."
Dr. Richard C. Schwartz and Dr. Sandra Z. Haslam, both from The Michigan State University said, "Ovarian hormones are strongly implicated in the etiology of breast cancer."
Dr. Wafik S. El-Deiry Founding Editorial Board Member of Oncotarget said, "Breast cancer is the most commonly diagnosed cancer and is the number three cause of cancer-related death in United States women."
Dr. Arieh Eden from the Department of Anesthesiology, Critical Care and Pain Medicine at the Lady Davis Carmel Medical Center in Haifa, Israel said in their Oncotarget Research Paper, "Sepsis affects millions of individuals annually worldwide, with a mortality of greater than 25%" and according to the Cancer | Sepsis Alliance "Having cancer and undergoing certain treatments for cancer, such as chemotherapy, can result in a weakened immune system, putting you at higher risk for developing an infection that could lead to sepsis. Sometimes incorrectly called blood poisoning, sepsis is the body's often deadly response to infection." https://www.sepsis.org/sepsisand/cancer/
Dr. Gil Atzmon from the Department of Medicine and Genetics at Albert Einstein College of Medicine, in the Bronx, NY
Dr. Electron Kebebew from Stanford University said, "Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy."
Dr. Steven Horvath and Dr. Brian Chen said, "DNA methylation-based biomarkers, often referred to as ‘epigenetic age’ or ‘epigenetic clock’, are robust estimators of chronological age of an individual."
Dr. Lawrence M. Pfeffer from the Department of Pathology and Laboratory Medicine, and Center for Cancer Research at the University of Tennessee Health Science Center in Memphis, TN, said "By targeted arrays and RNA-sequence analysis, we found STAT3 regulated genes in GICs that are important in various pro-tumorigenic pathways."
Dr. Tapasree Roy Sarkar from The University of Texas MD Anderson Cancer Center as well as The Texas A&M University said, "Angiogenesis is a normal physiological process that entails the development of new blood vessels through remodeling of a pre-existing vasculature, underpinned by endothelial cell sprouting, proliferation, and fusion"
Dr. Michael P. Lisanti and Dr. Federica Sotgia from The Department of Translational Medicine, School of Science, Engineering and Environment (SEE) at The University of Salford in Greater Manchester United Kingdom said, "The earliest retrospective study of the COVID-19 outbreak in Wuhan, China, published in the Lancet, was among one of the first clinical studies to identify older age as a significant risk factor for in-hospital mortality, suggesting that advanced chronological age may play an epidemiological role in patient clinical outcomes."
Dr. Bishal Gyawali from the Institute of Cancer Policy, London and Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital
Dr. Marie E. Wood from The Robert Larner MD College of Medicine, University of Vermont said, "Several models are available for estimation of breast cancer risk; the most widely used include the Gail, Claus, and International Breast Cancer Intervention Study (IBIS) models."
Dr. Beatrice Aramini from The University of Modena and Reggio Emilia said, "Cancer stem cells (CSCs) constitute a cancer cell subpopulation similar to the other stem cell types in terms of self-renewal and multilineage differentiation potential but drive tumor development besides heterogeneity and dissemination of cancer cells."
Dr. Nerymar Ortiz-Otero from the Meinig School of Biomedical Engineering, Cornell University
Dr. Marina P. Antoch from the Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY
Dr. Michael H. Roehrl from the Department of Pathology, Memorial Sloan Kettering Cancer Center as well as the Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center said, "Colorectal cancer (CRC) is one of the most prevalent malignant tumors and the third leading cause of cancer deaths worldwide."
Dr. Hua Li and Dr. Shashwat Sharad from the Center for Prostate Disease Research, Department of Surgery, Uniformed Services University of the Health Sciences as well as the Walter Reed National Military Medical Center, Bethesda, Maryland, USA said in their Oncotarget article, "Prostate cancer is the most commonly diagnosed male malignancy and second leading cause of cancer-related deaths in the USA."
Dr. Gina Abdelaal from The Northumbria University said, "Iron is vital for normal cell growth and survival."
Dr. Sandip Pravin Patel, Dr. Karen Yun and Dr. Karen Mccowen from the University of California San Diego
Dr. Steve Horvath said, "Cognitive aging is on a continuum from normality, to mild cognitive impairment (MCI), to dementia."
Dr. Susan E. Erdman from the Division of Comparative Medicine, at the Massachusetts Institute of Technology in Cambridge, MA, United States said, "The global burden of chronic inflammatory diseases is increasing at alarming rates."
Dr. Brian A. Van Tine from The Washington University in St. Louis, The St. Louis Children's Hospital as well as The Siteman Cancer Center said, "Head and neck cancer are a group of heterogeneous tumors with an estimated 644,000 new cases per year worldwide."
Dr. Herbert Levine from The Center for Theoretical Biological Physics at Rice University as well as The Department of Physics at Northeastern University and Dr. Mohit Kumar Jolly from The Centre for BioSystems Science and Engineering at The Indian Institute of Science said "Epithelial-Mesenchymal Transition (EMT) is a cell biological process involved in driving cancer metastasis and therapy resistance?the two grand clinically unsolved challenges."
Dr. Derrick Haslem and Dr. Lincoln Nadauld from the Precision Genomics Program, Intermountain Healthcare, Saint George, UT
Dr. Blanca Molins from The IDIBAPS, Hospital Clínic de Barcelona said, "Age-related macular degeneration (AMD) is the primary cause of irreversible vision loss among the ageing population worldwide."
Dr. Jennifer Y. Sheng from The Johns Hopkins Sidney Kimmel Comprehensive Cancer Center said, "...survivorship guidelines recommend that weight loss should be a priority for overweight/obese survivors."
Interview with Dr. Leo Tsuda from the Center for Development of Advanced Medicine for Dementia National Center for Geriatrics and Gerontology Obu, Aichi, Japan
Dr. Velia M. Fowler and Dr. Catherine Cheng said, "The eye lens is required for fine focusing of light onto the retina to form a clear image, and the function of the lens is intimately tied to its shape, biomechanical properties, transparency and refractive index."
Dr. Judith Campisi from The Buck Institute for Research on Aging as well as The University of California said, "The stringent cell growth arrest associated with cellular senescence is determined, among other mechanisms, by activities of cyclin-dependent kinase inhibitor proteins p16Ink4a and p21Cip1/Waf1, encoded by the Cdkn2a and Cdkn1a loci, respectively."
Dr. Sridhar Mani from Medicine and Genetics of The Albert Einstein College of Medicine, Bronx, NY
Dr. Martin-Montalvo said, "The increasing burden of age-related diseases highlights the importance of uncovering the mechanisms underlying the aging process."
Dr. J. Kimble Frazer from the Department of Cell Biology and the Department of Pediatrics, Section of Pediatric Hematology-Oncology, as well as the Department of Microbiology & Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA said, "Acute lymphoblastic leukemia (ALL) and the related malignancy lymphoblastic lymphoma (LBL) dominate pediatric oncology, together representing over one third of all childhood cancer."
Dr. Cameron Hill from the Randall Centre for Cell and Molecular Biophysics, Kings College London, and Dr. Paul Morgan from the University of Birmingham, United Kingdom, discuss the topic of an editorial that was co-authored by Dr. Hill - along with Dr. Jason Tallis from Coventry University Centre for Sport, School of Life Sciences, Coventry, West Midlands
Dr. Alexei Kurakinn and Dr. Dale E. Bredesen said, "Alzheimer’s disease has become a global epidemic, rapidly advancing in the last decade to become the 5th leading cause of death globally and the 3rd leading cause of death in high-income countries."
Dr. Aditya Kulkarni from The Lantern Pharma, Inc. said, "KEAP1, KRAS, TP53 and STK11/LKB1 are among the commonly altered genes with considerable clinical prevalence in non-small cell lung cancers (NSCLC)."
Dr. Junhua Li and Dr. Lei Feng said, "Tea has been a popular beverage since antiquity, with records referring to consumption dating back to the dynasty of Shen Nong (approximately 2700 BC) in China."
Dr. Dae Joon Kim and Liza Morales from the Department of Biomedical Sciences, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX,
Dr. Ariella Oppenheim from the Department of Hematology, Hebrew University Faculty of Medicine, Jerusalem, Israel
Dr. Junhua Li and Dr. Lei Feng said, "Tea has been a popular beverage since antiquity, with records referring to consumption dating back to the dynasty of Shen Nong (approximately 2700 BC) in China."
Dr. Yves C. Chabu from The University of Missouri said, "Conventional cancer chemotherapies are not specific and, as such, generate significant morbidities."
Jean-Pol Detiffe, Chief Executive Officer of OncoDNA, said: "This dataset demonstrates the utility and power of OncoDNA's proprietary, living database and our holistic approach to genomic and molecular profiling. For oncologists, the study suggests our testing and analysis products could represent the best way to make informed therapeutic decisions in clinical practice. Not only were OncoDNA's recommendations followed in the majority of cases, but the study also suggests that our comprehensive testing and analyses could represent the best approach for obtaining useful molecular insight, while reducing physicians' exposure to irrelevant aberrations. As we continue to expand our business through Europe and beyond, these results will help raise awareness of the benefits of our product offering among oncologists and further the healthcare industry's ability to prescribe precision medicine."
