Gerontology Press Releases

I comprehensively researched and crafted press releases across diverse aging fields, spanning yeast to mammals, delving into cellular senescence, age-related diseases like cancer and Alzheimer’s. My focus extended to prevention, treatment, anti-aging strategies, and drug development.

Specifically, I explored the pivotal role of signal transduction pathways, like mTOR, seeking methods to extend lifespan by slowing down aging. The research aimed at advancing age-related disease treatments, validating anti-aging drugs, and preventing cancer by inhibiting aging, recognizing the link between age, cancer, and diseases like COVID-19.

Green tea catechins enhance fitness and lifespan of Caenorhabditis elegans

Green tea polyphenol-containing water extended the lifespan of male C57BL/6 mice

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/CLINICAL STUDIES/CLINICAL TRIALS

12-Nov-2021

Iron: an underrated factor in aging

Iron, which can then react with and damage cellular structures, which in turn can lead to organ damage and the deterioration associated with aging

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

12-Nov-2021

A systemic multidisciplinary approach to study aging in sled dogs

The use of canines for aging studies works towards the obvious goal of prolonging the healthspan of humans and addresses the potential for extending the healthy years of humans’ closest companions – domestic dogs

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

10-Nov-2021

Proliferation, migration, & invasion of pathways: gallbladder cancer

The 5-year survival rate for GBC is 13%, and the median survival time is below 1 year

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

9-Nov-2021

Helicobacter pylori infection and risk for developing dementia

Currently, there are more than 50 million people with dementia worldwide, and this number will increase to 152 million by 2050

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

8-Nov-2021

Deductive reasoning & principles of particle physics applied to aging research

There are two ways to consider aging and any other process: deductive and inductive reasoning

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

5-Nov-2021

Reduced uremic metabolites are prominent feature of sarcopenia

Although many studies have examined human blood serum or plasma, these authors' whole blood analysis covers metabolites from both cellular and non-cellular compartments

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER

4-Nov-2021

Alleviating vascular dysfunction & amyloid burden in Alzheimer’s

HBOT improved cognitive performance in animal models of Alzheimer’s disease, and improved the metabolic status and cognitive scores of AD

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

3-Nov-2021

Cerebrovascular abnormalities in Alzheimer’s disease: adrenergic approach

Added to a growing body of evidence implicating cerebrovascular abnormalities as a core feature of AD rather than a simple comorbidity

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

2-Nov-2021

Cerebrovascular abnormalities in Alzheimer’s disease: adrenergic approach

Added to a growing body of evidence implicating cerebrovascular abnormalities as a core feature of AD rather than a simple comorbidity

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

1-Nov-2021

Neurodegeneration in subjective cognitive decline

Dr. Nira Cedres from The Karolinska Institutet as well as The Stockholm University said, "Multiple pathologies can co-exist in cognitively unimpaired individuals, causing neurodegeneration years before the onset of cognitive decline."

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

11-Oct-2021

Protein processing impairment in Parkinson’s disease

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/PARKINSONS DISEASE

8-Oct-2021

N6-methyladenosine and its clinical relevance in cognitive dysfunctions

These findings suggest that m6A methylations as potential biomarkers and therapeutic targets for cognitive dysfunction

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

6-Oct-2021

Senescence-associated hyper-activation to inflammatory stimuli in vitro

Authors hypothesized that SnCs contribute to the increased severity of infectious diseases and infection-mediated cytokine storm in the elderly

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/INFECTIOUS DISEASES/MICROBIAL INFECTIONS/VIRAL INFECTIONS/COVID 19

4-Oct-2021

The role of age at menarche and age at menopause in Alzheimer’s disease

Our bidirectional MR study provided no evidence for a causal effect of the genetically determined age at menarche or age at menopause on AD susceptibility, or vice versa

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/MEDICAL SPECIALTIES/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

4-Oct-2021

Cellular senescence in lymphoid organs and immunosenescence

In the wake of an ongoing pandemic that disproportionately affects the elderly, immunosenescence as a function of age has become a topic of great importance

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELLULAR SENESCENCE

4-Oct-2021

Dietary supplementation with green tea catechins and cocoa flavanols

Cocoa, but not GTE, reduced aging-associated microgliosis and increased the proportion of neuroprotective microglial phenotypes

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

1-Sep-2021

Spatiotemporal dynamics of γH2AX after acute irradiation

The Aging-US results suggest that early life irradiation-induced PDDF at later stages of animal life may be related to the brain aging and shortened life expectancy of irradiated animals.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CELL THERAPIES

30-Aug-2021

A model of the aged lung epithelium in idiopathic pulmonary fibrosis

They propose that this simple yet powerful tool could help uncover new biological mechanisms and assist in developing new pharmacological tools to treat the disease

PEER-REVIEWED PUBLICATION | /SCIENTIFIC COMMUNITY/RESEARCH PROGRAMS/CANCER RESEARCH

30-Aug-2021

Modulating cancer cell responses during drug-induced senescence

The authors suggest that DNMT2/TRDMT1 gene knockout in selected experimental settings may potentiate some adverse effects associated with chemotherapy-induced senescence

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/GENE THERAPY

30-Aug-2021

miRNAs generated from Meg3-Mirg locus are downregulated during aging

This study published in Aging-US, provides new data concerning the mechanisms of natural aging and highlights the robustness of the miRNA modulation during this process

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENETIC MATERIAL/RNA/MICRORNA

27-Aug-2021

Multidomain interventions: a randomized controlled feasibility trial

Dr. Seong Hye Choi from The Inha University School of Medicine and Dr. Jee Hyang Jeong from The Ewha Womans University School of Medicine said, "As life expectancy increases worldwide, dementia has rapidly become a huge public health problem."

PEER-REVIEWED PUBLICATION | /RESEARCH METHODS/OBSERVATIONAL STUDIES/CONTROL GROUPS

27-Aug-2021

Responses of neurons, astrocytes, & microglia to G-quadruplex stabilization

PDS promotes DNA DSBs in neurons, astrocytes and microglial cells, but fails to downregulate Brca1 in astrocytes and microglia, indicating differences in DNA damage and repair pathways between brain cell types

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/GLIA/ASTROCYTES

25-Aug-2021

Cognition and action: Executive functions to motor control in older adults

These data suggest a central role for working memory updating in complex motor performance and contribute to our understanding of how individual differences in executive functioning relate to movement control in older adults.

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/PSYCHOLOGICAL SCIENCE/COGNITIVE PSYCHOLOGY/COGNITION/COGNITIVE CONTROL

25-Aug-2021

Inducing apoptosis and enhancing cytoprotective autophagy in colon cancer

Dr. You-Cheng Hseu from The China Medical University as well as The Asia University said, "Colorectal cancer (CRC) is the third most deadly and fourth most frequently identified cancer in the world."

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELL DEATH/CELL APOPTOSIS

23-Aug-2021

Identification of a novel potential biomarker for hepatocellular carcinoma

The network, revealed in this Aging-US study, may help comprehensively elucidate the ceRNA mechanisms driving HCC, and provide novel candidate biomarkers for evaluating the prognosis of HCC

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA/HEPATOCELLULAR CARCINOMA

23-Aug-2021

Calycosin inhibits breast cancer cell migration and invasion

These findings, published in Aging-US, demonstrated that calycosin inhibited EMT and progression of breast cancer cells by suppressing BATF/TGFβ1 signaling

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS/BREAST CANCER CELLS

23-Aug-2021

Biomarkers of biochemical recurrence in prostate adenocarcinoma

Dr. Fuzhong Xue from The Shandong University said, "Prostate cancer is a common malignant tumor and the leading cause of cancer-related mortality in men."

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/PROSTATE TUMORS

19-Aug-2021

HMGA1 promotes gastric cancer growth and metastasis

These Aging-US findings suggest that HMGA1 promotes GC growth and metastasis by transactivating SUZ12 and CCDC43 expression, highlighting HMGA1 as a potential prognostic biomarker in the treatment of GC

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/METASTASIS

19-Aug-2021

PirB functions as an intrinsic suppressor in hippocampal neural stem cells

These Aging-US findings suggest that PirB inhibits the self-renewal and differentiation capacities of neural stem cells

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/STEM CELLS/NEURAL STEM CELLS

19-Aug-2021

MiR-513b-5p represses autophagy by targeting PIK3R3

Consequently, they concluded in their Aging-US Research Output that miR-513b-5p repressed autophagy during the malignant progression of HCC by targeting PIK3R3. MiR-513b-5p may be applied as a therapeutic target for HCC

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA/HEPATOCELLULAR CARCINOMA

17-Aug-2021

Hub candidate network for hepatocellular carcinoma

These findings, published in Aging-US, indicated a certain RBP-circRNA regulatory network potentially involved in the pathogenesis of HCC, which provides novel insights into the mechanism of study and biomarker identification for HCC

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/CANCER/CARCINOMA/HEPATOCELLULAR CARCINOMA

17-Aug-2021

Prognostic prediction of patients with lung adenocarcinoma

This Aging-US study identified a novel FRG signature that could be used to evaluate and predict the prognosis of LUAD patients

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

9-Aug-2021

PTEN nuclear translocation enhances neuronal injury after hypoxia-ischemia

Dr. Jing Zhao from The Affiliated Hospital of North Sichuan Medical College said, "Hypoxia-ischemia (HI) during fetal and neonatal development can cause damage to neurons, leading to neurological defects and even death"

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLULAR PHYSIOLOGY/CELLULAR PROCESSES/NUCLEAR TRANSLOCATION

9-Aug-2021

High-calorie diet before calorie restriction on skeletal muscles

This Aging-US study identified a novel FRG signature that could be used to evaluate and predict the prognosis of LUAD patients

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/CLINICAL MEDICINE/MEDICAL TREATMENTS/CANCER TREATMENTS

9-Aug-2021

Anti-miRs against miR-142-3p reduces angiogenesis and microglia activation

"These www.Aging-US.com data strongly support the unprecedented importance of miR-142- 3p-dependent vascular-inflammation axis during CNV progression, through microglia activation"

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/VISION DISORDERS/MACULAR DEGENERATION

30-Jul-2021

Aging phenotype of MDPL syndrome associated with impaired DNA repair capacity

'These www.Aging-US.com results suggest an alteration in DNA replication/repair function of POLD1 as a primary pathogenetic cause of MDPL.'

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/DNA REPAIR

22-Mar-2021

Aging and rejuvenation - a modular epigenome model

This www.Aging-US.com study reports that epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/DNA METHYLATION

22-Mar-2021

Adiposity & Muscle Function: a community-based cross-sectional study

Dr. Wei-Shiung Yang from The National Taiwan University Hospital said, "The impact of muscle mass or muscle strength on functional disability has attracted high levels of attention in the medical community".

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/MUSCULOSKELETAL SYSTEM/MUSCLES

22-Mar-2021

DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

@Blagosklonny concluded in his www.Aging-US.com Research Output that here he discussed new evidence that normal aging is not caused by accumulation of molecular damage or telomere shortening.

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/DEMOGRAPHY/VITAL STATISTICS/LIFE SPAN

8-Mar-2021

Hyperbaric oxygen therapy impact on telomere length & immunosenescence

"In this Aging-US study, the most significant change was noticed in B cells which increased at the 30th session, 60th session and post HBOT by 25.68%±40.42 , 29.39%±23.39 and 37.63%±52.73, respectively."

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/BIOCHEMISTRY/BIOMOLECULES/NUCLEIC ACIDS/DNA/CHROMOSOMES/CHROMOSOME STRUCTURE/TELOMERES

8-Mar-2021

High-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19

'The www.Aging-US.com authors developed over 800 new C. sativa cultivars and hypothesized that high-CBD C. sativa extracts may be used to down-regulate ACE2 expression in target COVID-19 tissues.'

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/INFECTIOUS DISEASES/MICROBIAL INFECTIONS/VIRAL INFECTIONS/COVID 19

8-Mar-2021

Sulforaphane promotes C. elegans longevity and healthspan

'The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of C. elegans through insulin/IGF-1 signaling.'

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/DEMOGRAPHY/VITAL STATISTICS/LIFE SPAN

3-Feb-2021

A pro-diabetogenic mtDNA polymorphism in mitochondrial-derived peptide

'The m.1382A>C polymorphism is associated with susceptibility to T2D in men, possibly interacting with exercise, and contributing to the risk of T2D in sedentary males by reducing the activity of MOTS-c.'

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/GENETICS/MOLECULAR GENETICS/GENE EXPRESSION/POLYMORPHISM

2-Feb-2021

Screening Alzheimer's disease by facial complexion using artificial intelligence

This Aging-US study showed that deep learning programs such as Xception have the ability to differentiate the faces of patients with mild dementia from that of patients without dementia.

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/PSYCHOLOGICAL SCIENCE/COGNITIVE PSYCHOLOGY/COGNITIVE DISORDERS/DEMENTIA

2-Feb-2021

Sulforaphane promotes C. elegans longevity and healthspan

"The results in this Aging-US research output, indicate that sulforaphane prolongs the lifespan and healthspan of C. elegans through insulin/IGF-1 signaling."

PEER-REVIEWED PUBLICATION | /SOCIAL SCIENCES/DEMOGRAPHY/VITAL STATISTICS/LIFE SPAN

2-Feb-2021

Anserine protected against cognitive decline

The Aging-US results suggest that anserine protects elderly persons with MCI from cognitive declines by suppressing MPO-mediated neuroinflammatory responses.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/NEUROSCIENCE/CLINICAL NEUROSCIENCE/NEUROLOGY/NEUROLOGICAL DISORDERS/NEURODEGENERATIVE DISEASES/ALZHEIMER DISEASE

2-Feb-2021

Growth factor beta type 1 and hypoxia-inducible factor 1 transcription complex

"The Aging-US authors report for the first time that in human breast cancer, AML and embryonic cells, HIF-1 and AP-1 upregulate the expression of TGF-β"

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/CELL BIOLOGY/CELLS/CANCER CELLS/BREAST CANCER CELLS

25-Jan-2021

Nicotinamide mononucleotide in degenerative model of retinal detachment

'This Aging-US article concludes that NMN administration exerts neuroprotective effects on photoreceptors'

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/SENSE ORGANS/EYE/PHOTORECEPTORS

25-Jan-2021

PAM (PIK3/AKT/mTOR) signaling in glia: potential contributions to brain tumors

'The consideration of aberrant PIK3/AKT/mTOR signaling in glia during aging elucidates several therapeutic opportunities for brain tumors'.

PEER-REVIEWED PUBLICATION | /LIFE SCIENCES/ORGANISMAL BIOLOGY/ANATOMY/TISSUE/NEOPLASMS/BRAIN TUMORS

25-Jan-2021

'From Causes of Aging to Death from COVID-19' by Mikhail V. Blagosklonny

Aging-US recently published "From Causes of Aging to Death from COVID-19" by Blagosklonny et al. which reported that COVID-19 is not deadly early in life, but mortality increases exponentially with age - which is the strongest predictor of mortality.

PEER-REVIEWED PUBLICATION | /HEALTH AND MEDICINE/DISEASES AND DISORDERS/INFECTIOUS DISEASES/MICROBIAL INFECTIONS/VIRAL INFECTIONS/COVID 19

5-Oct-2020